Disease-A-Month
Volume 55, Issue 6 , Pages 365-372 , June 2009

Grass Pea and Neurolathyrism (Lathyrus sativus L.)

References 

  1. Kislev ME. Origin of the cultivation of Lathyrus sativus and L. cicera (Fabaceae). Econ Bot. 1989;43:262–270
  2. Cohn DF, Kislev ME. Neurolathyrism. Adler Museum Bull. 1987;13:5–8
  3. Cohn DF, Streifler M. Neurolathyrism (Historical notes). Koroth. 1978;7:147–152
  4. Cantani A. Latirismo (Lathyrismus). Morgagni. 1873;15:745–765
  5. Gebreab T, Wolde Gabriel Z, Maffi M, et al. Neurolathyrism (A review and report of an epidemic). Ethiop Med J. 1978;16:1–11
  6. Kessler A. Lathyrismus. Psychiatrie Neurologie. 1947;113:345–376
  7. Getahun H, Lambein F, Vanhoorne M, et al. Pattern and associated factors of the neurolathyrism epidemic in Ethiopia. Trop Med Int Health. 2002;7:118–124
  8. Spencer PS, Ludolph AC, Kisby GE. Neurologic diseases associated with use of plant components with toxic potential. Environ Res. 1993;62:106–113
  9. Tekle-Haimanot T, Abegaz BM, Wuhib E, et al. Pattern of Lathyrus sativus (grass pea) consumption and β-N-oxalyl-α,β-diaminopropionic acid (β-ODAP) content of food samples in the lathyrism endemic region of northwest Ethiopia. Nutr Res. 1993;13:1113–1126
  10. Haque A, Hossain M, Khan JK, et al. New findings and symptomatic treatment for neurolathyrism, a motor neuron disease occurring in North West Bangladesh. Paraplegia. 1994;32:193–195
  11. De Bruyn A, Van Haver D, Lambein F, et al. Chemical properties of the natural neurotoxin of Lathyrus sativus 3-N-oxalyl-2,3-diamino-propanoic acid (beta-ODAP), its nontoxic 2-N-oxalyl isomer, and its hydrolysis product 2,3-diamino-propanoic acid (DAPRO) by 1H- and 13C-NMR spectroscopy. Nat Toxins. 1993;1:328–340
  12. Khan JK, Kebede N, Kuo YH, et al. Analysis of the neurotoxin β-ODAP and its α-isomer by precolumn derivatization with phenylisothiocyanate. Anal Biochem. 1993;208:237–240
  13. Yan Z-Y, Spencer PS, Li Z-X, et al. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry. 2006;67:107–121
  14. Chase RA, Pearson S, Nunn PB, et al. Comparative toxicities of alpha- and beta-N-oxalyl-l-alpha, beta-diaminopropionic acids to rat spinal cord. Neurosci Lett. 1985;55:89–94
  15. Lambein F, Khan JK, Kuo YH. Free amino acids and toxins in Lathyrus sativus seedlings. Planta Med. 1992;58:380–381
  16. Jha K. Effect of the boiling and decanting method of Khesari (Lathyrus sativus) detoxification on changes in selected nutrients. Arch Latinoam Nutr. 1987;37:101–107
  17. Moges G, Johansson G. Flow injection assay for the neurotoxin β-ODAP using an immobilized glutamate oxidase reactor with prereactors to eliminate glutamate interferences. Anal Chem. 1994;66:3834–3839
  18. Ressler C. Neurotoxic amino acids of certain species of Lathyrus and vetch (Vicia sativa). Fed Proc. 1964;23:1350–1353
  19. Lambein F, Khan JK, Kuo YH, et al. Toxins in the seedlings of some varieties of grass pea (Lathyrus sativus). Nat Toxins. 1993;1:246–249
  20. Qureshi IA, Sethi DK, Salunke DM. Purification, identification and preliminary crystallographic studies of an allergenic protein from Lathyrus sativus. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006;62:869–872
  21. Streifler M, Cohn PF. Chronic central nervous system toxicity of the chickling pea (Lathyrus sativus). Clin Toxicol. 1981;18:1513–1517
  22. Spencer PS. Food toxins, AMPA receptors, and motor neuron diseases. Drug Metab Rev. 1999;31:561–587
  23. Weaver AL, Spittell JA. Lathyrism. Mayo Clin Proc. 1964;39:485–489
  24. Mehta T, Zarghami NS, Cusick PK, et al. Tissue distribution and metabolism of the Lathyrus sativus neurotoxin, l-3-oxalylamino-2-aminopropionic acid in the squirrel monkey. J Neurochem. 1976;27:1327–1331
  25. Kusama-Eguchi K, Kusama T, Suda A, et al. Partial involvement of group I metabotropic glutamate receptors in the neurotoxicity of 3-N-oxalyl-l-2,3-diaminopropanoic acid (l-beta-ODAP). Biol Pharm Bull. 2004;27:1052–1058
  26. Sachdev S, Sachdev JC, Puri D. Morphological study in a case of lathyrism. J Indian Med Assoc. 1969;52:320–322
  27. Pratap Rudra MP, Singh MR, Junaid MA, et al. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem. 2004;37:318–322
  28. Ludolph AC, Hugon J, Dwivedi MP, et al. Studies on the aetiology and pathogenesis of motor neuron diseases. 1 (Lathyrism: clinical findings in established cases). Brain. 1987;110:149–165
  29. Haque A, Hosain M, Wouters G, et al. Epidemiological study of lathyrism in northwestern districts of Bangladesh. Neuroepidemiology. 1996;15:83–91
  30. Spencer PS, Roy DN, Ludolph A, et al. Lathyrism: evidence for role of the neuroexcitatory amino acid BOAA. Lancet. 1986;2:1066–1067
  31. Paissios CS, Demopoulos T. Human lathyrism: a clinical and skeletal study. Clin Orthop. 1982;23:236–249
  32. Haque A, Hossain M, Lambein F, et al. Evidence of osteolathyrism among patients suffering from neurolathyrism in Bangladesh. Nat Toxins. 1997;5:43–46
  33. Valdivieso R, Quirce S, Sainz T. Bronchial asthma caused by Lathyrus sativus flour. Allergy. 1988;43:536–539
  34. Anton Girones M, de la Hoz Caballer B, Munoz Martin T, et al. Occupational rhinoconjunctivitis and asthma by exposure to Lathyrus sativus flour. Allergol Immunopathol. 2005;33:326–328
  35. Chen X, Wang F, Chen Q, et al. Analysis of neurotoxin 3-N-oxalyl-L-2,3-diaminopropionic acid and its alpha-isomer in Lathyrus sativus by high-performance liquid chromatography with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatization. J Agric Food Chem. 2000;48:3383–3386
  36. Zhao L, Chen X, Hu Z, et al. Analysis of beta-N-oxalyl-l-alpha, beta-diaminopropionic acid and homoarginine in Lathyrus sativus by capillary zone electrophoresis. J Chromatogr A. 1999;857:295–302
  37. Yigzaw Y, Larsson N, Gorton L, et al. Liquid chromatographic determination of total and beta-N-oxalyl-l-alpha, beta-diaminopropionic acid in Lathyrus sativus seeds using both refractive index and bioelectrochemical detection. J Chromatogr A. 2001;929:13–21
  38. Wang F, Chen X, Chen Q, et al. Determination of neurotoxin 3-N-oxalyl-2,3-diaminopropionic acid and non-protein amino acids in Lathyrus sativus by precolumn derivatization with 1-fluoro-2,4-dinitrobenzene. J Chromatogr A. 2000;883:113–118
  39. Drory VE, Rabey MJ, Cohn DF. Electrophysiologic features inpatients with chronic neurolathyrism. Acta Neurol Scand. 1992;85;:401–403
  40. Misra UK, Sharma RP. Peripheral and central conduction studies in neurolathyrism. J Neurol Neurosurg Psychiatr. 1994;57:572–577

 This article was published in: Barceloux DG. Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Toxic Plants, and Venomous Animals. Hoboken, NJ: John Wiley & Sons, 2008. pp. 62-66. Copyright © 2008 by John Wiley & Sons, Inc. Reprinted with permission of John Wiley & Sons, Inc.

PII: S0011-5029(09)00031-5

doi: 10.1016/j.disamonth.2009.03.006

Disease-A-Month
Volume 55, Issue 6 , Pages 365-372 , June 2009