Disease-A-Month
Volume 55, Issue 6 , Pages 380-390 , June 2009

Pepper and Capsaicin (Capsicum and Piper Species)

References 

  1. Govindarajan VS. Capsicum—production, technology, chemistry, and quality. I (History, botany, cultivation and primary processing). CRC Crit Rev Food Sci Nutr. 1985;22:109–176
  2. Fett DD. Botanical briefs: Capsicum peppers. Cutis. 2003;72:21–23
  3. Thresh LT. Isolation of capsaicin. Pharm J. 1846;6:941–942
  4. Nelson EK, Dawson LE. The constitution of capsaicin—the pungent principle of Capsicum, III. J Am Chem Soc. 1923;45:2179–2181
  5. Nelson EK. The constitution of capsaicin—the pungent principle of Capsicum. J Am Chem Soc. 1919;41:1115–1121
  6. Hass JS, Whipple RE, Grant PM, et al. Chemical and elemental comparison of two formulations of oleoresin capsicum. Sci Justice. 1997;37:15–24
  7. Steffee CH, Lantz PE, Flannagan LM, et al. Oleoresin capsicum (pepper) spray and “in-custody deaths”. Am J Forensic Med Pathol. 1995;16:185–192
  8. Hautkappe M, Roizen MF, Toledano A, et al. Review of the effectiveness of capsaicin for painful cutaneous disorders and neural dysfunction. Clin J Pain. 1998;14:97–106
  9. Mason L, Moore RA, Derry S, et al. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ. 2004;328:991
  10. Buck SH, Burks TF. The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev. 1985;38:179–226
  11. Masada Y, Hasimoto K, Inoue T, et al. Analysis of the pungent principles of Capsicum annum by combined gas chromatography-mass spectrometry. J Food Sci. 1971;36:858–860
  12. Cordell GA, Araujo OE. Capsaicin: identification, nomenclature, and pharmacotherapy. Ann Pharmacother. 1993;27:330–336
  13. Jung MY, Bock JY, Baik SO, et al. Effects of roasting on pyrazine contents and oxidative stability of red pepper seed oil prior to its extraction. J Agric Food Chem. 1999;47:1700–1704
  14. Roy AK, Sinha KK, Chourasia HK. Aflatoxin contamination of some common drug plants. Appl Environ Microbiol. 1988;54:842–843
  15. Olajos EJ, Salem H. Riot control agents: pharmacology, toxicology, biochemistry and chemistry. J Appl Toxicol. 2001;21:355–391
  16. Govindarajan VS, Sathyanarayana MN. Capsicum-production, technology, chemistry, and quality. Part V (Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences). Crit Rev Food Sci Nutr. 1991;29:435–474
  17. Nakatani N, Inatani R, Ohta H, et al. Chemical constituents of peppers (Piper spp.) and application to food preservation: naturally occurring antioxidative compounds. Environ Health Perspect. 1986;67:135–142
  18. Rathnawathie M, Buckle KA. Determination of piperine in pepper (Piper nigrum) using high-performance liquid chromatography. J Chromatogr. 1983;264:316–320
  19. Farag SE, Abo-Zeid M. Degradation of the natural mutagenic compound safrole in spices by cooking and irradiation. Nahrung. 1997;41:359–361
  20. Balbaa SI, Karawya MS, Girgis AN. The capsaicin content of capsicum fruits at different stages of maturity. Lloydia. 1968;31:272–274
  21. Weinberg RB. Hunan hand. N Engl J Med. 1981;305:1020
  22. Carpenter SE, Lynn B. Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin. Br J Pharmacol. 1981;73:755–758
  23. Myers BM, Smith JL, Graham DY. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol. 1987;82:211–214
  24. Khachik F, Spangler CJ, Smith JC, et al. Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal Chem. 1997;69:1873–1881
  25. Diehl AK, Bauer RL. Jalaproctitis. N Engl J Med. 1978;299:1137–1138
  26. Tominack RL, Spyker DA. Capsicum and capsaicin—a review: case report of the use of hot peppers in child abuse. Clin Toxicol. 1987;25:591–601
  27. Lopez-Carrillo L, Lopez-Cervantes M, Robles-Diaz G, et al. Capsaicin consumption, Helicobacter pylori positivity and gastric cancer in Mexico. Int J Cancer. 2003;106:277–282
  28. Lopez-Carrillo L, Hernandez Avila M, Dubrow R. Chili pepper consumption and gastric cancer in Mexico: a case-control study. Am J Epidemiol. 1994;139:263–271
  29. Toth B, Gannett P. Carcinogenicity of lifelong administration of capsaicin of hot pepper in mice. In Vivo. 1992;6:59–63
  30. Mrvos R, Krenzelok EP, Jacobsen TD. Toxidromes associated with the most common plant ingestions. Vet Hum Toxicol. 2001;43:366–369
  31. Williams SR, Clark RF, Dunford JV. Contact dermatitis associated with capsaicin: Hunan hand syndrome. Ann Emerg Med. 1995;25:713–715
  32. Greer JM, Rosen T, Tschen JA. Sweet's syndrome with an exogenous cause. Cutis. 1993;51:112–114
  33. Forrester MB, Stanley SK. The epidemiology of pepper spray exposures reported in Texas in 1998-2002. Vet Hum Toxicol. 2003;45:327–330
  34. Watson WA, Stremel KR, Westdorp EJ. Oleoresin capsicum (Cap-Stun) toxicity from aerosol exposure. Ann Pharmacother. 1996;30:733–735
  35. Fuller RW. Pharmacology of inhaled capsaicin in humans. Respir Med. 1991;85(suppl A):31–34
  36. Hathaway TJ, Higenbottam TW, Morrison JFJ, et al. Effects of inhaled capsaicin in heart-lung transplant patients and asthmatic subjects. Am Rev Respir Dis. 1993;148:1233–1237
  37. Chan TC, Vilke GM, Clausen J, et al. The effect of oleoresin capsicum “pepper” spray inhalation on respiratory function. J Forensic Sci. 2002;47:299–304
  38. Smith J, Greaves I. The use of chemical incapacitant sprays: a review. J Trauma. 2002;52:595–600
  39. Winograd HL. Acute croup in an older child (An unusual toxic origin). Clin Pediatr. 1977;16:884–887
  40. Billmire DF, Vinocur C, Ginda M, et al. Pepper-spray-induced respiratory failure treated with extracorporeal membrane oxygenation. Pediatrics. 1996;98:961–963
  41. Brown L, Takeuchi D, Challoner K. Corneal abrasions associated with pepper spray exposure. Am J Emerg Med. 2000;18:271–272
  42. Choudry NB, Fuller RW, Pride NB. Sensitivity of the human cough reflex: effect of inflammatory medicators prostaglandin E2, bradykinin, and histamine. Am Rev Respir Dis. 1989;140:137–141
  43. Blanc P, Liu D, Juarez C, Boushey HA. Cough in hot pepper workers. Chest. 1991;99:27–32
  44. Sheahan K, Page DV, Kemper T, et al. Childhood sudden death secondary to accidental aspiration of black pepper. Am J Forensic Med Pathol. 1988;9:51–53
  45. Adelson L. Homicide by pepper. J Forensic Sci. 1964;9:391–395
  46. Cohle SD. Homicidal asphyxia by pepper aspiration. J Forensic Sci. 1986;31:1475–1478
  47. Flintoff WM, Poushter DL. Aspiration of black pepper (A case report). Arch Otolaryngol. 1974;100:375–376
  48. Jerenitsch J, Leinmuller R. Quantification of nonylic acid vanillylamide and other capsaicinoids in the pungent principle of Capsicum fruits and preparation by gas-liquid chromatography on glass capillary columns. J Chromatogr. 1980;189:389–397
  49. Reilly CA, Crouch DJ, Yost GS, et al. Determination of capsaicin, nonivamide, and dihydrocapsaicin in blood and tissue by liquid chromatography-tandem mass spectrometry. J Anal Toxicol. 2002;26:313–319
  50. Nasrawi CW, Pangborn RM. Temporal effectiveness of mouth-rinsing on capsaicin mouth-burn. Physiol Behav. 1990;47:617–623
  51. Vogl TP. Treatment of Hunan hand. N Engl J Med. 1982;306:178
  52. Jones LA, Tandberg D, Troutman WG. Household treatment for “chile burns” of the hands. Clin Toxicol. 1987;25:483–491
  53. Lee DC, Ryan JR. Magnesium-aluminum hydroxide suspension for the treatment of dermal capsaicin exposures. Acad Emerg Med. 2003;10:688–690
  54. Lichtenberger LM, Romero JJ, Carryl OR, et al. Effect of pepper and bismuth subsalicylate on gastric pain and surface hydrophobicity in the rat. Aliment Pharmacol Ther. 1998;12:483–490

 This article was published in: Barceloux DG. Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Toxic Plants, and Venomous Animals. Hoboken, NJ: John Wiley & Sons, 2008. pp. 71-76. Copyright © 2008 by John Wiley & Sons, Inc. Reprinted with permission of John Wiley & Sons, Inc.

PII: S0011-5029(09)00033-9

doi: 10.1016/j.disamonth.2009.03.008

Disease-A-Month
Volume 55, Issue 6 , Pages 380-390 , June 2009